CRISPR interference (CRISPRi) is a novel method for specific gene knockdown.
The CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary SALL1-SDS3 repressor construct to block transcription of target genes, without cutting the DNA.

CRISPRi benefits
• CRISPR specificity – PAM-anchored targeting system
• Gentle knockdown – Knock genes down, not out
• Extended time course – Longer repression duration compared to siRNA
• Down-regulation within the gene’s native context

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